Terry K Smith Selected Research

Dolichol Monophosphate Mannose

3/2009

First small molecular inhibitors of T. brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African sleeping sickness.

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Terry K Smith Research Topics

Disease

17	African Trypanosomiasis (Nagana) 12/2020 - 12/2002
7	Alzheimer Disease (Alzheimer's Disease) 08/2020 - 01/2012
5	Infections 10/2021 - 09/2009
4	Leishmaniasis 01/2021 - 01/2010
3	Malaria 10/2021 - 03/2014
3	Mitochondrial Diseases (Mitochondrial Disease) 08/2020 - 01/2017
3	Neglected Diseases 10/2018 - 05/2014
3	Neoplasms (Cancer) 06/2013 - 06/2010
2	Parasitic Diseases (Parasitic Disease) 01/2021 - 01/2018
2	Chagas Disease (American Trypanosomiasis) 01/2018 - 01/2015
2	Communicable Diseases (Infectious Diseases) 01/2018 - 06/2010
1	Thrombosis (Thrombus) 02/2021
1	Type 2 Diabetes Mellitus (MODY) 02/2021
1	Diabetes Mellitus 01/2021
1	Babesiosis (Piroplasmosis) 12/2019
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2018
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017
1	Visceral Leishmaniasis (Kala Azar) 12/2016
1	Acquired Immunodeficiency Syndrome (AIDS) 01/2016
1	Eczema 02/2015

Drug/Important Bio-Agent (IBA)

12	Pharmaceutical PreparationsIBA 01/2021 - 11/2004
5	Proteins (Proteins, Gene)FDA Link 10/2021 - 01/2016
4	EnzymesIBA 07/2019 - 01/2012
3	Amyloid (Amyloid Fibrils)IBA 08/2020 - 01/2017
3	Amyloid beta-PeptidesIBA 01/2017 - 01/2016
3	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA 07/2006 - 12/2002
2	LipidsIBA 01/2021 - 08/2020
2	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 08/2020
2	benzothiazoleIBA 07/2019 - 01/2016
2	Oxidoreductases (Dehydrogenase)IBA 07/2019 - 01/2017
2	Alcohol Dehydrogenase (Alcohol Dehydrogenase (NAD+))IBA 07/2019 - 01/2017
2	miltefosine (Impavido)IBA 12/2016 - 04/2014
2	Phosphatidylinositols (Phosphatidylinositol)IBA 03/2014 - 12/2002
2	Biological ProductsIBA 09/2012 - 09/2009
2	SphingolipidsIBA 01/2012 - 06/2010
1	Protein SIBA 10/2021
1	Meglumine AntimoniateIBA 01/2021
1	Clemastine (Clemastine Fumarate)FDA LinkGeneric 01/2021
1	HydrolasesIBA 01/2021
1	Amino Acids FDA Link 12/2020
1	CytokinesIBA 12/2019
1	Nucleic AcidsIBA 01/2018
1	SirtuinsIBA 01/2018
1	Aromatic Amino Acids (Aromatic Amino Acid)IBA 01/2018
1	erythrose 4-phosphateIBA 01/2018
1	ribose-5-phosphateIBA 01/2018
1	bisnaphthalimidopropylspermidineIBA 01/2018
1	Amphotericin B (Amphotericin)FDA LinkGeneric 06/2017
1	GuanidinesIBA 01/2017
1	ThioureaIBA 01/2017
1	Monoamine Oxidase (MAO)IBA 01/2017
1	frentizoleIBA 01/2017
1	Peptides (Polypeptides)IBA 01/2017
1	Phosphatidylcholines (Phosphatidylcholine)IBA 12/2016
1	phosphatidylethanolamineIBA 12/2016
1	liposomal amphotericin B FDA Link 12/2016
1	Drug CombinationsIBA 12/2016
1	Inositol (Myoinositol)IBA 06/2015
1	Biomarkers (Surrogate Marker)IBA 02/2015
1	quinolineIBA 06/2014
1	dactolisibIBA 06/2014
1	Phosphotransferases (Kinase)IBA 06/2014
1	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 03/2014
1	chamuvarininIBA 06/2013
1	NifurtimoxIBA 02/2013
1	Eflornithine (Ornidyl)FDA Link 02/2013
1	CTP synthetaseIBA 09/2012
1	ProdrugsIBA 07/2012
1	3-bromoacivicinIBA 02/2011
1	D-myo-inositol-3-phosphate synthaseIBA 01/2011
1	Phospholipids (Phosphatides)FDA LinkGeneric 06/2010
1	SphingomyelinsIBA 06/2010
1	pteridine reductaseIBA 01/2010
1	Dolichol Monophosphate MannoseIBA 03/2009
1	3- (3,5- dichlorophenyl)- 1- methyl- 2,5- pyrrolidinedione (DPMS)IBA 03/2009
1	N- acetylglucosaminyl- phosphatidylinositol de-N-acetylaseIBA 06/2005
1	AcetylesteraseIBA 12/2002

Therapy/Procedure

9	Therapeutics 10/2018 - 03/2009
1	Drug Therapy (Chemotherapy) 01/2015